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Deficiency of VMAT2 elevates monoamine turnover, evidenced by reduced levels of DA, norepinephrine, 5-hydroxytryptamine and histamine in catecholaminergic neurons, leading to up-regulation of amine-synthesizing enzymes [23]

evaluated the role of oxidative stress by measuring MDA levels which were significantly higher in the lesional skin areas than the nonlesional areas in patients with plantar warts.[] Similar cross-sectional studies performed by Sasmaz et al .[] and Cokluk et al .[] found significant increase in catalase activity and MDA levels in patients with nongenital and genital warts, respectively, when compared with the control group

Across preclinical studies, Epitalon has shown: Telomerase activation and telomere extension: Via TRAP assays and fibroblast lifespan extension beyond the Hayflick limit Epigenetic remodeling: Reversal of chromatin aging, histone modulation, and gene promoter binding Redox homeostasis: Increased antioxidant enzymes (SOD, NQO1, catalase) and reduced ROS, lipid peroxidation, and DNA damage Circadian restoration: Upregulation of AANAT/pCREB, normalized melatonin and cortisol rhythms, and clock gene modulation in humans Cancer risk reduction: Reduced tumor multiplicity and delayed onset in HER-2/neu and colon cancer models

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